Continuous-Flow Hydration-Condensation Reaction
News Mar 20, 2012
A simple, practical and efficient continuous-flow hydration-condensation protocol was developed for the synthesis of α,β-unsaturated ketones starting from alkynes and aldehydes by employing a heterogeneous catalyst in a flow microwave. The procedure presents a straightforward and convenient access to valuable differently substituted chalcones and can be applied on multigram scale.
The article is published online in Belstein Journal of Organic Chemistry and is free to access.