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CSEM NADIS Technology Finds Key Applications in Biochemistry and Biology

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Scientists from CSEM, Switzerland, and Lund University, Sweden, have successfully developed attovial-based antibody microarrays. Each individual spot of the array has dimensions that approach the nanometer scale: this is the first time such a level of miniaturization has been achieved. There will be resulting applications in Proteomics R&D. An article describing the work was recently published in the scientific journal Proteomics.

Conventional antibody microarrays feature typical spot sizes of 100 to 300 µm, and contain hundreds of different antibodies. These values have now been improved using a novel microarray structure developed at Lund University, in combination with NADIS, a nanoscale liquid-delivery technique pioneered at CSEM. This led to a 100-fold reduction in spot size, allowing a greatly increased number of antibodies. This opens the way for global proteome analysis, where over 20,000 spots will be needed on a protein chip, CSEM expects.

NADIS, short for Nanoscale Dispensing, was developed to deposit liquid volumes as small as attoliters (10-18 liters). No conventional liquid-delivery technique, such as spotting or printing, is able to deliver small spot sizes comparable to NADIS, the manufacturers have claimed.

These important results are the outcome of a collaboration between proteomics specialists at the Department of Immunology at Lund University, and the technology specialists from the Nanotechnology Division at CSEM. Another key application of CSEM’s NADIS technology was demonstrated last year, when tiny amounts of liquids were injected into living cells. This pioneering work made NADIS the smallest syringe in the world.