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Detecting Genetic Risk Factors For Type 1 Diabetes

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Researchers at the Steno Diabetes Centre in Copenhagen, Denmark, have announced that they are using Applied Biosystems' 7900HT Fast Real-Time PCR System with TaqMan® Gene Expression Assays and Low Density Array cards to identify the genetic risk factors for type 1diabetes.

With the Applied Biosystems' GeneScan® and GeneMapper® software, the researchers are genotyping and analysing the sequences of samples from individuals and families with type 1diabetes.

Prof Flemming Pociot, Head of the Department of Molecular T1D Genetics at the Centre said, “This equipment has served us extremely well, it is well used and it is easy to get support from Applied Biosystems.”

“We are particularly impressed by the TaqMan Low Density Array cards. They give very little variation - which is wonderful - and make data analysis much more straightforward.”

“They are also more sensitive than microarrays for some genes. It is important that we can design arrays with a limited number of genes, for instance, those located in a specific region of the genome, and can run many samples addressing the same expression profiles.”

The data from these studies are being pooled together with data from all over the world as part of the international Type 1 Diabetes Genetics Consortium, which was in part instigated by the Steno Diabetes Centre.