Finnish Researchers Discover Genes Inhibiting the Spread of Prostate Cancer
News May 15, 2012
The research team of Professor Johanna Ivaska (University of Turku and VTT Technical Research Centre of Finland) screened dozens of prostate cancers using gene silencing and discovered mechanisms of that inhibit the spread of cancer cells.
Published in the Journal of Cell Science, the study shows that cancer cell adhesive activity, which is easy to measure in a laboratory setting, is directly linked to the ability of the cancer cells to metastasize.
As a result, screening for regulators of cancer cell activity can lead to the discovery of new candidates for pharmaceutical development.
The study describes dozens of new regulators of cancer cell activity; employing gene silencing mechanisms on two of these regulators (CD9 and MMP8) was found to have a direct impact on the spreading of cancer cells.
In the study, researchers Teijo Pellinen and Juha Rantala from Professor Ivaska's research team utilized the cell spot micro array technology developed by VTT.
The method allows researches to study the impacts of all genes in an entire genome in a single experiment.
The study was published in the Journal of Cell Science, a distinguished publication in the field of cell biology.
Could This Be a "Silver Bullet" for Preventing and Treating Colon Cancer?News
A team of scientists targeted the gene CtBP with a drug known as HIPP (2-hydroxy-imino phenylpyruvic acid) and were able to reduce the development of pre-cancerous polyps by half.READ MORE
FDA Grants Full Approval to Blinatumomab for Acute Lymphoblastic LeukemiaNews
TheFDA has changed its accelerated approval of blinatumomab (Blincyto®) for some patients with acute lymphoblastic leukemia to a full approval and expanded the approved indications for its use.READ MORE
Comments | 0 ADD COMMENT
11th International Conference on Cancer Stem Cells
Jun 11 - Jun 13, 2018