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Alzheimer's Plus Neuroinflammation in a Dish

News   Jul 31, 2018 | Original Story from Massachussetts General Hospital

Fully Replicating Alzheimer's Disease in a Dish

Six days after activated microglia (red) were added to the outer chamber of the new microfluidic device, the inflammatory cells migrate through channels into the inner chamber, containing cultured neurons and astrocytes (green) with gene variants associated with familial Alzheimer's disease. Upon arrival in the inner chamber, the microglia directly attack neurons and raise levels of key inflammatory factors. Credit: Joseph Park, Ph.D., Doo Yeon Kim, Ph.D., Rudolph E. Tanzi, Ph.D., and Hansang Cho, Ph.D.; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease



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