Gel Boosts Stem Cell Studies
News Jan 10, 2013
Scientists have developed a family of compounds that can support the growth of human embryonic stem cells on a large scale.
Their technique could have applications for use in drug testing or treatments for conditions such as such as Huntington’s and Parkinson’s diseases.
The new materials, which are water-based gels, act as a tiny scaffold to which cells can cling as they grow.
Normally cells must be grown on expensive biological surfaces that can carry risk of contamination.
Once cells have multiplied sufficiently for their intended purpose, the gels can be cooled, enabling the stem cells to drop off the scaffold without becoming damaged.
The new approach surpasses existing techniques of separating cells by mechanical or chemical means, which carry a greater risk of damage to cells.
Scientists say the materials could offer a means of enabling the stem cells to be produced in large numbers efficiently and with a lowered risk of contamination.
This could facilitate research, drug screening programmes and clinical applications that call for large numbers of cells.
Researchers at the University developed the materials by screening hundreds of potential compounds for their ability to support stem cell growth.
From a shortlist of four, one has been found to be effective, and researchers say the remaining three show similar potential.
Stem cells provide a powerful tool for screening drugs as they can be used to show the effects of drugs on cells and systems within the body.
The study, published in Nature Communications, was supported by the European Union Framework 7 Grant Funding.
The gels are being developed under licence by technology company Ilika.
Researchers Develop New Method to Generate Human AntibodiesNews
Researchers hope their approach will help researchers rapidly generate therapeutic antibodies for the treatment of infectious diseases and other conditions such as cancer.READ MORE
Large-Scale Production of Living Brain Cells Enables Entirely New ResearchNews
After performing a biopsy on the patient, the skin cells are transformed into brain cells that effectively imitate the disease and the age of the patient.READ MORE
U.S. Study of Dapivirine Ring in Lactating Women Finds Little Drug Gets Into Breast MilkNews
The antiretroviral drug dapivirine that is released from an experimental vaginal ring to protect against HIV is absorbed in very low concentrations into breastmilk.READ MORE
Comments | 0 ADD COMMENT
EMBL Conference: European Conference of Life Science Funders and Foundations
Apr 19 - Apr 20, 2018