Invitrogen Develops new Technology to Promote Safer Stem Cell Therapies
News May 14, 2009
Invitrogen, a division of Life Technologies, has announced a new technology to enable the development of safer stem cell therapies. Dynabeads’ SSEA-4 addresses a key challenge in translational research, by separating undifferentiated stem cells from those that are differentiated.
Scientists from Invitrogen and the Buck Institute for Age Research, located in Novato, California, collaborated in developing this solution that depletes greater than 99 % of undifferentiated human embryonic stem cells from differentiated populations. They are presenting data on this new technology at the International Society for Cellular Therapy Meeting in San Diego.
Human embryonic stem cell research is one of the fastest growing areas in cell biology. These cells have unlimited proliferative capacity and can differentiate into multiple types, providing an infinite resource for many potential translational medicine applications.
A key issue for translational stem cell researchers is the ability to reliably identify and isolate undifferentiated hESCs, which are not considered as suitable for transplantation as those which are differentiated, because of the potential of unregulated cell growth. Their objective is to obtain pure and homogenous cell populations, which will help to ensure the safe development and manufacturing of therapeutics.
Dynabeads SSEA-4 achieves this by utilizing magnetic beads that latch onto a common marker on embryonic and induced pluripotent stem cells, removing them from a culture in less than 45 minutes. This leaves behind highly pure and differentiated cells that are unaffected by the Process.
Paul Pickering, General Manager of Invitrogen Cell Therapy Systems Business at Life Technologies said, “Dynabeads SSEA-4 is an innovative and highly effective solution that addresses one of the key challenges in the development of safer stem cell therapies. It was made possible through the collaboration of several technologies and business groups from different parts of the company coming together to offer a single solution to a problem faced by many of our stem cell customers.”
Xianmin Zeng, Ph.D., Associate Professor, Buck Institute, “Using Dynabeads SSEA-4, we are able to deplete greater than 99% of pluripotent cells in neural cell populations derived from pluripotent cells, which are likely targets for transplant therapy for neurodegenerative disorders.”
Innate Reaction of Hematopoietic Stem Cells to Severe InfectionsNews
Researchers at the University of Zurich have shown for the first time that hematopoietic stem cells detect infectious agents themselves and begin to divide, without signals from growth factors.READ MORE
Using Milk Protein to 3D-Imprint Muscle and Bone CellsNews
Researchers from the University of Canterbury are replicating a 3D imprint of cells onto films made of milk protein. The films then gradually degrade, leaving the grown tissue behind.READ MORE
Comments | 0 ADD COMMENT
EMBL Course: Transgenic Animals - Micromanipulation Techniques
Apr 10 - Apr 11, 2018
EMBO Practical Course: Extracellular Vesicles: From Biology to Biomedical Applications
Apr 09 - Apr 13, 2018
EMBO | EMBL Symposium: Tissue Self-Organisation: Challenging the Systems
Mar 11 - Mar 14, 2018