Joining Forces to Develop “Nephron-on-a-Chip" to Accelerate Drug Discovery in Kidney Disease
A new consortium to accelerate the discovery of novel drugs to treat kidney diseases was announced Monday 6 November. The NEPLEX (nephron on a chip with cellular and extracellular matrix complexity) consortium, comprising leading academic institutions including the Universities of Bristol and Cambridge, and Evotec AG, will combine key technologies to develop and build a novel drug discovery device ("Nephron-on-a-Chip").
The consortium's aim is to develop a functional nephron — which is the basic structural and functional unit of the kidney — on a chip device that reflects both the filtration area as well as the resorption area of a human kidney. The functional nephrons will be based on fully characterised human cell lines and iPSC-derived human cells. It will merge state-of-the-art microfluidics technology established at the University of Cambridge with world-class expertise in iPSC technology and kidney disease from the University of Bristol, the Mario Negri Institute in Bergamo and from Evotec AG.
Professor Moin Saleem and his group from the University of Bristol will contribute human kidney cell lines focusing on the resorption unit, Dr Yan Yan Shery Huang and her lab from the University of Cambridge will develop the glomerular part of the chip, Dr Christodoulos Xinaris and his colleagues from the Mario Negri Institute will provide human iPSC lines and expertise.
Evotec will add its state-of-the-art iPSC and kidney disease platforms. The device will allow testing of drug candidates in a fully human nephron already in the pre-clinic and thereby improve and accelerate drug discovery in the field of kidney diseases.
Dr Cord Dohrmann, Chief Scientific Officer of Evotec, commented: "We are very pleased to have teamed up with three leading academic institutions in such exciting area of medicine. Developing fully human and functional organotypic systems for pre-clinical drug discovery with the possibility to include human genetics will be a major step towards personalised and more disease-relevant drug candidates."
Professor Saleem, who is based at the Bristol Medical School: Tranlastional Health Sciences, added: "Bristol Renal is delighted to forge this collaborative project with Evotec, building on a productive academic-industry collaboration over the past five years, utilising our unique resources, and forming part of an innovative working relationship between clinicians, academia and industry which will significantly accelerate our route to discovery and translation."
This article has been republished from materials provided by University of Bristol . Note: material may have been edited for length and content. For further information, please contact the cited source.
A Greener Way to Make KetonesNews
Researchers at McGill University have discovered a new, more environmentally friendly way to make ketones, an important chemical ingredient in pharmaceuticals. While ketones are found in a wide range of useful chemicals, they are commonly prepared through energy-intensive, multi-step technologies that create significant chemical waste.READ MORE
Natoli Engineering Donates Equipment to Strengthen Purdue University’s Continuous Manufacturing ResearchNews
Natoli Engineering Company, Inc., the global leader in tablet compression tooling, continues to drive innovation in the tableting industry by donating a new NP-400 tablet press and related components to Purdue University in West Lafayette, IndianaREAD MORE
Insulin Goes Viral: Diabetes and Cancer-causing Mechanisms ExploredNews
Every cell in your body responds to the hormone insulin, and if that process starts to fail, you get diabetes. In an unexpected finding, scientists have identified four viruses that can produce insulin-like hormones that are active on human cells. The discovery brings new possibilities for revealing biological mechanisms that may cause diabetes or cancer.READ MORE
Comments | 0 ADD COMMENT
4th International Conference on Crystallography & Novel Materials
Nov 19 - Nov 20, 2018