We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Key Gene in Familial Alzheimer's Disease Regulates Neuronal Development
News

Key Gene in Familial Alzheimer's Disease Regulates Neuronal Development

Key Gene in Familial Alzheimer's Disease Regulates Neuronal Development
News

Key Gene in Familial Alzheimer's Disease Regulates Neuronal Development

This image shows the developing brain visualized with fluorescence laser scanning microscopy. It illustrates the neurons (blue) and growing axons (red and green). Credit: Author: INc-UAB
Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Key Gene in Familial Alzheimer's Disease Regulates Neuronal Development"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.Age is the most important factor in the development of neurodegenerative diseases such as Alzheimer's and cancer. Moreover, epidemiological studies indicate that there is an inverse correlation between suffering from Alzheimer's disease and cancer, although the mechanisms connecting these two pathologies remain unknown.

An international team of researchers led by Dr Carles Saura from the Institute of Neuroscience at UAB has unravel a mechanism crucial for the growth of neuron axons, a key process for the correct development of the brain.

According to the study, published in eLife, this mechanism requires presenilin, the main gene mutated in familial Alzheimer's disease. Its malfunction in this disease is what causes the abnormal accumulation of ?-amyloid in the brain in Alzheimer's disease patients. In this study, researchers demonstrate that presenilin is not only essential for regulating growth of neurons during brain development, but that it achieves this through the EphA3 receptor, a protein involved in several cancers. The relevance of this study is that it demonstrates the existence of a new cell mechanism that connects neurodegeneration with cancer.

"The discovery of this new signalling route is very relevant in the study of neurological disorders in which the morphology of the neuron axon is altered. Indeed, the implications of the study go beyond the brain given that the mechanism involves the EphA receptors, which play a key role in cancer", explains first author of the study Dr. Míriam Javier. According to Dr. Saura, "this research allows us to be optimistic about the development of common therapeutic strategies to fight neurological disorders and cancer."

Reference:

Javier-Torrent M, Marco S, Rocandio D, Pons-Vizcarra M, Janes PW, Lackmann M, Egea J, Saura CA. Presenilin/γ-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA. eLife. 2019 Oct 28. pii: e43646. doi: 10.7554/eLife.43646.

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

 

Advertisement