Lab Scale Manufacturing Using Continuous Crystallization
News Apr 15, 2014
In the webinar, in situ Process Analytical Technology (PAT) supported the development of a continuous plug flow crystallization platform that was able to meet production scale capacities in a lab setting while tightly controlling product attributes including particle size and shape distribution as well as yield and purity.
The Company is pleased to present a new installment in its thought-leading on-demand webinar series on Process Analytical Technology (PAT). The presentation, entitled “PAT-Based Design of Continuous Crystallizations,” explores specific methodology using ParticleTrack with Focused Beam Reflectance Measurement (FBRM) technology and related technologies for rapid plug-flow crystallization evaluation. Experiments using this methodology enabled a significant increase in production volume on lab-scale equipment.
Guest presenter Steven Ferguson, Biogen Idec, Cambridge, Massachusetts, developed the experiment series while working on his PhD as part of the Glennon Research Group (SSPC) at University College, Dublin. He also spent time at Novartis/ MIT Center for Continuous Manufacturing and Department of Chemical Engineering, as a post-doctoral associate with a focus on continuous crystallization, isolation and polymorphism.
A plug flow crystallization platform was developed that allowed PAT to be applied in situ via the use of novel flow cells to develop the anti-solvent crystallization of benzoic acid from aqueous ethanol solution. Equivalent tank-based MSMPR crystallizations using a pneumatic slurry transfer were also characterized using PAT. Both methods were then compared to equivalent batch crystallizations to gain their true performance measure.
As expected, continuous crystallization offered significantly intensified production, with approximately the same material generated by ~33 ml plug flow, 9 L MSMPR, and 42, 10,000 L batch crystallizations per annum. Furthermore, non-batch processing enabled production of a wider range of particle sizes and morphologies, with plug flow generating the highest possible supersaturation when feed and anti-solvent streams were perfectly mixed.
Despite its relatively small volume, under optimum conditions the plug flow device proved capable of producing 60 kilos a day of dry, isolated benzoic acid, providing production-scale pharmaceutical development with lab-scale equipment. Screening methodologies to determine if plug flow crystallization is appropriate for a particular chemistry is also explored, as is using FBRM and Particle Vision Microscopy (PVM) to monitor and maximize operating conditions.
Cell Recycling System Offers Therapeutic Entry Point for Rare Disease TreatmentNews
Scientists have demonstrated how an investigational drug works against a rare, fatal genetic disease, Niemann-Pick type C1 (NPC1).READ MORE
New Algorithms Help Extract 3-D Biological Structure from Limited DataNews
CAMERA researchers capitalize on their Multi-Tiered Iterative Phasing approach to determine molecular structure of proteins and viruses from X-ray free electron laser data.READ MORE
Cancer Cells Force Normal Cells to Act Like Viruses, Helping Tumors SpreadNews
Researchers reveal how cancer cells force normal cells to act like viruses – allowing tumors to grow, resist treatment, and spread.READ MORE
Comments | 0 ADD COMMENT
EMBL Conference: European Conference of Life Science Funders and Foundations
Apr 19 - Apr 20, 2018
EMBL Course: Target Engagement in Biology and Drug Discovery
Feb 19 - Feb 23, 2018
18th International Conference and Exhibition on Analytical & Bioanalytical Chromatographic Techniques
Nov 02 - Nov 03, 2017