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Marina Biotech Acquires RNA Delivery Assets of Novosom AG

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Marina Biotech, Inc announced that the Company has acquired the intellectual property of Novosom AG of Halle, Germany for its SMARTICLES® liposomal-based delivery system in an all-stock transaction.

The transaction further expands Marina's RNA delivery platform IP estate, which now includes DiLA2 delivery platform, tkRNAi (bacterial delivery platform), peptide nanoparticle delivery platform, and the SMARTICLES® liposomal delivery platform.

This acquisition significantly broadens the number of approaches Marina may take for systemic and local delivery of its proprietary UsiRNA therapeutics. The assets were acquired by Marina for approximately $5 million in unregistered Marina common stock. Additional terms of the agreement were not disclosed.

"We are pleased to have acquired the SMARTICLES® intellectual property estate of Novosom," stated J. Michael French, President and CEO of Marina Biotech.

French continued, "We believe that this technology and intellectual property estate, resulting from years of hard work and diligent IP prosecution on the part of Novosom, is a significant addition to our existing RNA delivery platforms and the IP estate of Marina Biotech. We plan to take full advantage of our new IP position by expanding our existing delivery capability to develop additional novel formulations for safe and effective systemic and local delivery of RNAi-based therapeutics."

The acquired Novosom patent estate represents a global portfolio including 42 issued or allowed patents and 31 pending patent applications providing broad coverage for liposomal delivery formulations, lipid compounds and nucleic acid chemistry.

"We believe the team at Marina Biotech is best positioned to further develop and exploit the advantages of the SMARTICLES® siRNA delivery platform," stated Elias Papatheodorou, Chief Executive Officer of Novosom, AG. "The addition of this technology to the expanding capability of Marina provides a truly unique opportunity in the sector to advance multiple RNAi-based therapeutics to the market."

Novosom's SMARTICLES® define a novel class of liposomes: fully charge-reversible particles. Novosom's liposomal vectors allow delivery of active substance (siRNA, antisense, decoy, etc.) inside the cell either by local or systemic administration. SMARTICLES® are designed to ensure: (1) stable passage through the bloodstream and (2) release of the nucleic acid payload within the target cell where it can engage the RNA interference pathway and exert its therapeutic effect.