NanoSight to Supply Instrumentation for Wellcome Trust Technology Development Grant
News May 22, 2009
NanoSight announces its involvement in the research and development of a new generation of novel instrumentation and methodologies aimed at measuring cellular nanoparticles in plasma and urine as biomarkers of a broad range of human disease conditions.
The research will be led by a world-class team from the University of Oxford which has recently been awarded a Wellcome Trust Technology Development Grant to work on the detection and characterization of nanoparticles in the early detection of human disease.
The team, which is led by Professor Ian Sargent at the Women's Centre of the John Radcliffe Hospital and is part of the Oxford Biomedical Research Centre, includes Professor Chris Redman (Obstetrics and Gynaecology), Dr Paul Harrison (Haemophilia and Thrombosis Centre), Professor Adrian Harris (Cancer Research UK) and Professor Peter Dobson (Begbroke Science Park). Other collaborators include Dr Leanne Hodson and Dr Frederick Karpe of the Oxford Centre for Diabetes, Endocrinology and Metabolism.
This exciting project involves the detection in the bloodstream of tiny fragments of cells, microparticles (100nm -1µm) and exosomes (30nm - 100nm), which are important for how cells communicate with each other. The numbers of these particles have been found to be significantly raised in the blood of patients with a number of diseases including heart disease, diabetes, pre-eclampsia, clotting problems and cancer, raising the possibility that measuring these particles in blood could be used to predict those at risk. However, their detection and size distribution measurement pose considerable challenges.
Alerted to NanoSight’s capabilities by Professor Dobson who recognized the fit between Professor Sargent’s needs and the NanoSight technology of which he was an early adopter, the Oxford group discussed their requirements with NanoSight’s scientists and, following very promising initial results, successfully applied for and were awarded £322,000 of Wellcome Trust funding in support of this important 3 year project.
Based on their innovative technology and capabilities, a novel fluorescence variant of NanoSight’s existing instrumentation will be developed by NanoSight in collaboration with the Oxford scientists to enable these micro- and nanoparticles to be detected and characterized in plasma and urine samples for the first time. By breaking through the limitations of existing fluorescence microparticle technology (such a flow cytometry) NanoSight hope to help open up a new class of diagnostic biomarkers in the fight against some of the most common and important diseases to afflict humans.
Researchers Develop New Method to Generate Human AntibodiesNews
Researchers hope their approach will help researchers rapidly generate therapeutic antibodies for the treatment of infectious diseases and other conditions such as cancer.READ MORE
Large-Scale Production of Living Brain Cells Enables Entirely New ResearchNews
After performing a biopsy on the patient, the skin cells are transformed into brain cells that effectively imitate the disease and the age of the patient.READ MORE
U.S. Study of Dapivirine Ring in Lactating Women Finds Little Drug Gets Into Breast MilkNews
The antiretroviral drug dapivirine that is released from an experimental vaginal ring to protect against HIV is absorbed in very low concentrations into breastmilk.READ MORE
Comments | 0 ADD COMMENT
EMBL Conference: European Conference of Life Science Funders and Foundations
Apr 19 - Apr 20, 2018
EMBL Course: Target Engagement in Biology and Drug Discovery
Feb 19 - Feb 23, 2018