We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
New Machine Learning Approach for Drug Repurposing
News

New Machine Learning Approach for Drug Repurposing

New Machine Learning Approach for Drug Repurposing
News

New Machine Learning Approach for Drug Repurposing

Credit: Suzy Hazelwood/ Pexels
Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "New Machine Learning Approach for Drug Repurposing"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

A new study presents a novel approach to drug repurposing that incorporates two-stage prediction and machine learning. The study is published in the peer-reviewed OMICS: A Journal of Integrative BiologyClick here to read the article now.


Drug repurposing is a method of developing new therapeutic use(s) for existing drugs, for which safety and pharmacokinetics have already been demonstrated in humans. This can significantly reduce the time, cost, uncertainty, and side effects associated with drug development.


Toshinori Endo, PhD, from Hokkaido University, and coauthors, propose a two-stage approach to drug repurposing. First, diseases are clustered by gene expression, with the thought that similar patterns of altered gene expression imply critical pathways shared in different disease conditions. Second, drug efficacy is determined based on the ability to reverse altered gene expression, and the results are clustered to identify repurposing targets. The investigators applied their approach and identified disease-specific gene expression and 20 drugs for repurposing.


“In this study, we took advantage of the large-scale identification and integration of different levels of information and biological insights that machine learning offers,” stated the investigators. “The efficiency and accuracy of drug candidate calculations were superior to those of previous studies, effectively improving the likelihood of successful drug repurposing, since all drugs were derived from agents effective against other diseases that clustered together in the same group.”


“Drug repurposing is of interest for therapeutics innovation in many human diseases including COVID-19. This study brings together three strands of methodological innovation: machine learning, unsupervised clustering of gene expression, and two-stage prediction. It is a timely contribution to the drug repurposing scholarship that should broadly inform life sciences discoveries, clinical trials, and translational medicine,” says Vural ÖzdemirMD, PhD, DABCP, Editor-in-Chief of OMICS.


Reference: Cong Y, Shintani M, Imanari F, Osada N, Endo T. A new approach to drug repurposing with two-stage prediction, machine learning, and unsupervised clustering of gene expression. OMICS J. Integr. Biol. 2022. doi: 10.1089/omi.2022.0026


This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

 
Advertisement