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New Mechanism for Controlling DNA Methylation in Cells

News   Mar 18, 2020 | Original story from The Institute of Medical Science, the University of Tokyo

 
New Mechanism for Controlling DNA Methylation in Cells

PAF15 in a complex with PCNA undergoes UHRF1-mediated dual mono-ubiquitylation, which is essential for DNMT1 recruitment, and subsequent maintenance of DNA methylation. Credit: Atsuya Nishiyama.

 
 
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