Optibrium Joins EUR 40 Million eTRANSAFE Project
News Oct 10, 2017
Optibrium™ announced that it will join the Enhancing Translational Safety Assessment through Integrative Knowledge Management (eTRANSAFE) project. eTRANSAFE is a five-year, 40 million EUR European collaboration between private and public organisations which seeks to improve safety assessment across the drug discovery and development process, ultimately with the aim of enabling the delivery of safer medicines.
Led by Novartis Pharma, with Bayer AG as deputy lead, the eTRANSAFE consortium partners 8 academic institutions, 6 SMEs and 12 pharma companies. It is funded by the Innovative Medicines Initiative 2 Joint Undertaking (IMI 2) together with the pharmaceutical industry and coordinated by the Fundació Institut Mar d'Investigacions Mèdiques (IMIM).
The eTRANSAFE project will carry out key efforts in the field of data standardisation and quality control, promoting the development and implementation of relevant data sharing policies and procedures that will have a great global impact in the community. eTRANSAFE will catalyse the transformation of drug safety modelling from monolithic applications and isolated data repositories to an open innovation ecosystem based on open standards, modular components and data integration services.
Dr Edmund Champness, Optibrium’s CSO, commented: “We are very proud to contribute to the eTRANSAFE project and this important effort to improve safety assessment in drug discovery. Optibrium look forward to leading the development of new visualisation approaches to understanding translational safety data, so that researchers can more effectively identify candidate drugs with better safety profiles. This will also support our own research into methods for the optimisation and selections of compounds, enabling researchers to efficiently focus their efforts on compounds with the best chance of success in becoming effective therapies.”
Project leader Francois Pognan from Novartis said: “The safety of new drug candidates in first clinical trials is extrapolated based on preclinical animal data. These extrapolations are made using solely the data generated for the project at hand, since a global and systematic analysis of predictivity of the entire collective historical data pool has never been made."
Deputy leader Thomas Steger-Hartmann from Bayer added: "It is often poorly known to what extent and frequency an observed effect in an animal species may translate into a human effect.”
Professor Ferran Sanz, coordinator of the project said: “eTRANSAFE will improve translational safety assessment and contribute to the key scientific policies, such as the reduce, reuse, recycle (3Rs) one and the FAIR principles for data sharing.”
Neural Computer Hears Like HumansNews
Modelling the human senses is an incredibly complex task. Our brains arrange cells into complex hierarchies that process information from our surroundings. Now, a group at MIT have created a model of the human auditory cortex that can hear sounds and music in the same way that humans do.READ MORE
Stable Beta-Amyloid Dimers Identified in Alzheimer’s BrainsNews
A recent study exploited state-of-the-art mass spectrometry to provide the first direct evidence of beta-amyloid dimers in patients with Alzheimer’s disease and points to the potential of these molecules as biomarkers. Beta-amyloid dimers may be the smallest pathological species that trigger Alzheimer’s disease.
Protein Target Identified That Could Prevent StrokesNews
Scientists have identified a protein, called GPR68, that senses blood flow and tells small blood vessels called arterioles when to dilate. The researchers believe medications that activate GPR68 could one day be useful to treat medical conditions, including ischemic stroke.READ MORE
Comments | 0 ADD COMMENT
2nd International Conference and Exhibition on Nanomedicine and Drug Delivery
May 21 - May 23, 2018