Potsdam Researchers Use Malvern Zetasizer Nano in Gold Nanoparticle Research
News Sep 09, 2009
Researchers at the University of Potsdam, Germany, are using a Zetasizer Nano ZS from Malvern Instruments to measure the dimensions and stability of gold nanoparticles smaller than 5 nm in diameter.
Gold has long been considered as an inert element, but in nanoparticulate form it can be very reactive. For particles under 5 nm the surface electrons increasingly dominate the properties of the surface and consequently of the system. This makes gold nanoparticles interesting for life science applications, in tagging viruses and cells for example.
Sabine Kosmella and Joachim Koetz made the ultrafine nanoparticles in a one-step reaction using gold chloride and an oligosaccharide-modified hyper-branched polyethylenimine (PEI). The PEI is a polyelectrolyte that acts as a reducing agent as well as a stabilizing agent. To make the particles, a mixture of gold chloride and PEI in solution is heated to 100 degC. This results in a dispersion of gold nanoparticles, which turn the solution red.
With the Zetasizer Nano the researchers were able to show that the average diameter of the particles was less than 5 nm and to determine the zeta potential of the dispersion, an indicator of its stability.
"Being able to measure particle size is important for the determination of the hydrodynamic radius of the particles including the polymer shell in comparison to other methods like TEM, visualizing the particle radius without polymer shell" said Dr Kosmella.
The Zetasizer Nano ZS from Malvern Instruments enables the measurement of both particle size, from 0.6nm to 6000 nm, and zeta potential in a single instrument. The technology built into the system provides the sensitivity required for measuring dilute proteins and polymers, as well as the ability to measure emulsions and suspensions at high concentrations.
Rechargable Antibacterial Coating - Just Add Bleach!News
Stainless steel is the gold standard for kitchen appliances and cookware, described as modern and sleek. But bacteria can grow on stainless steel surfaces, contaminating food. Current coatings available on the market are pricey and potentially harmful, so scientists have now developed an affordable specialized polymer coating for such surfaces that they can recharge with bleach treatments.READ MORE
New Chemical Synthesis Process: Synergy of Two Catalysts in One FlaskNews
Researchers report the one-step synthesis of a ketone from an aldehyde by the combination of thiazolium N-heterocyclic carbene and palladium/bisphosphine catalysts in one flask. The two catalysts function in a synergistic manner. This study is expected to lead to new synthesis processes of precursor compounds for medications.READ MORE
Nanotechnology Detects Molecular Biomarker for OsteoarthritisNews
For the first time, scientists have been able to measure a specific molecule indicative of osteoarthritis and a number of other inflammatory diseases using a newly developed technology. This preclinical study used a solid-state nanopore sensor as a tool for the analysis of hyaluronic acid.READ MORE
Comments | 0 ADD COMMENT
World Congress on Advanced Pharmacy and Clinical Research
Jul 16 - Jul 17, 2018