Latest Posters
Poster
Dual Dopant Approach for Simultaneous LC-APPI-MS/MS Analysis of Low and High Proton Affinity Pesticides
The objectives of the work detailed in this poster was to explore dual dopant approach to maximizing APPI sensitivity for simultaneous analysis of low and high proton affinity compounds.
Poster
A Triple Ionization Source for LC/MS
This poster reports the development of a triple ionization source consisting of ESI, APCI and APPI sources. The source uses two probes, one for ESI and a nebulizer/vaporizer for APCI and APPI.
Poster
Characterizing a Nasal Spray Formulation from Droplet to API Particle size
Interaction of a nasal spray product with the patients’ body depends on key variables such as the particle size of the delivered droplets and the suspended active pharmaceutical ingredient (API). The particle size of the drug can be an important parameter for the rate of dissolution and availability to sites of action within the nose.
Poster
Fully Automated LC-MS/MS-based Determination of Bosentanand its Metabolites in Dried Blood Spots using the SCAP™ DBS System
Dried Blood Spot (DBS) analysis is a very promising alternative to conventional whole blood and plasma analysis used in drug discovery and development or later in therapeutic drug monitoring with well documented advantages.
Poster
Trace Analysis of Isothiazolinones in Water Samples by Large-Volume Direct Injection Liquid Chromatography Tandem Mass Spectrometry
Isothiazolinones are used as preservatives, biocides and desinfectants in variety of industrial and domestic applications. The purpose of this study was to develop and optimize an LC–MS/MS method that would enable the determination without any derivatization or preconcentration step of isothiazolinones used in membrane technology for water purification and in household products, at levels relevant for the water cycle.
Poster
Reversed-Phase Point-of-use Purifier for the Removal of Trace Organics in High Purity Water
Recent developments of Liquid Chromatography instrumentation, such as UHPLC coupled with mass spectrometry, have increased the separation efficiency and sensitivity. Unfortunately, there are some
unwelcome consequences. One of these is the detection of trace contamination in the solvents used to prepare mobile phases. The aim of this work was to design a cartridge which produces high water quality for very sensitive LC-MS applications.
Poster
Mechanistic Prediction of Volume of Distribution: The Influence of Plasma and Tissue Binding
Plasma protein binding (usually expressed as a percentage bound fraction %PPB) and volume of distribution (Vd) are the two major parameters characterizing drug disposition in the body.
Poster
Probabilistic Predictive Model of the Human Liver Microsomal Metabolism Regioselectivity
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task which is performed only in late drug development phases.Therefore, the ability to predict possible sites of human liver microsomal metabolism using in silico techniques would be highly beneficial for any medicinal chemist.
Poster
GALAS Modeling Methodology Applications in the Prediction of the Drug Safety Related Properties
Early computational evaluation of drug candidate properties related to its pharmaceutical safety (such as hERG inhibition induced cardiotoxicity or CYP3A4 inhibition responsible various unwanted drug-drug interactions) is becoming increasingly important in the drug discovery process.
Poster
Sequence-independent Selective Amplification of mRNAs over rRNAs
Standard mRNA amplifications for "All-Exon" microarrays and for bacterial RNAs are impossible with small samples and with degraded RNAs, because removal of rRNAs must precede universal, non-selective RNA amplification.
This pre-treatment with magnetic beads is cumbersome, requires high amounts of starting material, is not universal for all species and degraded RNAs are not suitable.
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