Latest Posters
Poster
Some thiazole derivatives as potent antiproliferative agents with CDK2/Cycin E/A inhibitory activities
We report synthesis and biological evaluation of novel thiazole derivatives. High throughput screening of various compounds for their anti-proliferative activity led to the identification of thiazolo-thiones as potential candidate for Lung cancer (NCl-H23, NClH510A, NCI-H522) and breast cancer (MDA-MB-453/231/468, MCF-7). The most potent compounds were also screened for their inhibitory activity against CDK2/ Cyclin E/A which are considered as promising targets for lung and breast cancer.
Poster
Organic azide synthesis in microreactors: from optimization to lab scale production
The formation of benzyl azide by diazotransfer to benzyl amine was screened and subsequently scaled up using continuous flow chemistry.
Poster
Automated Microreactor Optimisation of the Swern-Moffatt Oxidation at Elevated Temperatures
Optimisation of the selective Swern-Moffatt oxidation of benzyl alcohol to benzaldehyde by varying five experimental parameters in an automated microreactor setup.
Poster
Predicting hepatotoxicity: Reactive metabolite trapping using glutathione and freshly isolated hepatocytes
This poster presents our results to date using clozapine (a compound known to be associated with GSH-adduct formation) as substrate and using stable isotope GSH (GSH13C2,15N) to enhance specificity. In addition, all analyses have been conducted using an Waters Acquity UPLC-MS/MS. Results we have obtained in hepatocytes are compared against findings using human liver microsomes (HLM).
Poster
Partial characterization of nitrate signaling pathway of Arthrospira platensis PCC 7345
The present study is to elucidate the signaling network involved in nitrate uptake and assimilation of Arthrospira platensis. Expression of adenylate cyclase, cyaC was found to be nitrate signal dependent. The involvement cAMP was also observed in different levels of nitrate signaled assimilatory pathway. We have used differential display to identify a histidine kinases in the nitrate signaling of Arthrospira platensis.
Poster
In-silico Prediction of Human Intestinal Absorption and human oral bioavailability
Human intestinal absorption (HIA) and human oral bioavailability are two important ADME properties in drug design. We built some in-silico models for classification of human intestinal absorption (HIA) and human oral bioavailability by Kohonen’s self-organizing Neural Network (KohNN), and several quantitative models for prediction of HIA and bioavailability of several subset compounds datasets by Support Vector Machine (SVM).
Poster
How to Produce and Validate an IND Report / Validation Report in Just a Few Days
How to Produce and Validate an IND Report / Validation Report in Just a Few Days The IDBS E-WorkBook Suite is an enterprise, data-centric ELN designed to support validated experiment data and IP capture for the entire large and small molecule preclinical development environment. It enables data required for experiments and reports to be captured, stored and searched in a consistent manner across all departments.
Poster
Label-Free High Throughput Homogeneous ADME Assays
SoPRano is a novel label-free screening platform using specifically derivatised gold nanoparticles in solution form. It enables SPR-based screening in high throughput using simple homogenous assay protocols on a standard absorbance plate-reader. SoPRano is flexible and can be applied to many affinity screening applications.
Poster
Antioxidant Capacity and Polyphenol Content of Brown Seawedds after Heat Processing
Seaweeds or marine macroalgae are renewable living resources which are also used as food, feed and fertilizer in many parts of the world. They are able to produce a great variety of secondary metabolites. Results showed that the heat processing not only enhanced the contents of biologically active compounds in seaweeds but also the biological activity associated with these compounds as compared to the unprocessed seaweeds.
Poster
Digital Volumetric Imaging of Angiogenesis in Tissue Engineered Constructs
Accurate identification of functional vasculature is of critical importance in evaluating construct integration. Digital volumetric imaging (DVI) is an automated serial sectioning and microscopic imaging technique that can bridge the resolution gap between micro-computed tomography and conventional histology. We use DVI to study in vivo vascularization of tissue engineering constructs in a variety of settings.
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