Latest Posters

ACrylic polyers such as PMMA are used as coatings binders. We studied the sorption of acetone, methylethylketone, and toluene in PMMA thin fims ( 1-5 microns) using the Masscal G1

This study was performed to test the involvement of d-opioid receptors in dyskinesia induced by L-DOPA in hemiparkinsonian rats. Our results indicate that endogenous enkephakins modulate the expression of L-DOPA-induced dyskinesia. It also appears that d-opioid receptors located on corticostriatal terminals could be involved in the development of these dyskinesia. These results confer on d-opioid antagonists interesting properties in the improvement of Parkinson’s disease therapy.

The current study was performed to investigate the role of cannabinoid (CB) receptors on the cholinergic contraction of isolated human airways. Results obtained with WIN55,212-2 (CB1/CB2 agonist), JWH-133 (CB2 agonist) and CB receptor selective antagonists suggest that CB1-receptor stimulation inhibits the cholinergic contraction in human isolated bronchi through stimulation of prejunctional receptors, located to post-ganglionic cholinergic nerves.

The combination of flow chemistry and microwave heating offers a unique opportunity to scale out heterogeneous microwave-assisted organic reactions. The feasibility of this setup is depending on the presence of a microwave effect, safety issues and energy efficiency.

a new type of preparative liquid chromatography columns is described with applications of the efficiency

To investigate the level of SAa2,6Gal and a2,3Gal linked receptors on human bronchial epithelial cells, and relate this to the ability of both human and avian influenza viruses to infect bronchial epithelial cells

Thermo Fisher Scientific Inc. have announced the availability of a new technical poster demonstrating the importance of configurability and flexibility in laboratory information management systems (LIMS) design for life sciences and high throughput screening applications.

Time-dependent inhibition of cytochrome P450 (CYP) metabolism can lead to nonlinear pharmacokinetics and drug-drug interactions. Recent guidance from the USFDA and drug failures attributable to toxicity that may have a basis in time-dependent inhibition, have elevated interest in this long-known undesirable property of drug candidates.

The Parallel Artificial Membrane Permeability Assay (PAMPA) is a well-accepted screening assay for ADME properties (membrane permeability).

Human MRP2 and rat Mrp2 inside-out vesicles were prepared from Spodoptera frugiperda (Sf9) insect cells expressing the corresponding transporters. MRP2 mediated and ATP dependent uptake of 3H-LTC4 was conducted using the rapid filtration system in the absence or presence of MgATP.