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The EU chemical policy REACH, effective on June 2007, regulates the registration, evaluation and authorization of chemicals. Investigations on the effects of neurotoxic and developmental-neurotoxic substances are required by European and US-American test guidelines. However, at the moment these tests are based on animal experiments contradicting society claims to abolish animal experiments and to implement the 3R-principle. The resulting problem is… How to pair REACH and the 3Rs?

Current presentation is dedicated to case studies and illustrates diversity of the projects. Cases representing different projects combine the same analytical platform we utilize for metabolomics study of blood plasma and urine. While pattern recognition presents certain challenges but rather ones that can be resolved, identification of low abundant unknown biomarkers is critical for the field and offers significant technical challenge in spite of considerable progress in modern analytical techn

Current presentation is dedicated to case studies and illustrates diversity of the projects. Cases representing different projects combine the same analytical platform we utilize for metabolomics study of blood plasma and urine. While pattern recognition presents certain challenges but rather ones that can be resolved, identification of low abundant unknown biomarkers is critical for the field and offers significant technical challenge in spite of considerable progress in modern analytical techn

Much high-quality toxicity information is held within organisations rather than being in the public domain. Organisations would benefit from sharing this data with each other in a reciprocal manner where commercial sensitivity issues allow.

Many problems in analytical spectroscopy require insight from several different techniques to adequately resolve the problem. A common difficulty with using several techniques is often the ability to manage the various data types and making the data available for review, analysis and reporting.

Nodal involvement in bladder cancer is an independent indicator of prognosis. This study employed an iterative machine learning process called genetic programming on quantitative expression values of 70 genes to classify primary urothelial carcinoma samples into those associated with or without nodal metastasis. The generated rules showed a strong predilection for ICAM1, MAP2K6 and KDR resulting in gene expression motifs that cumulatively suggested a pattern ICAM1>MAP2K6>KDR for node positive ca

For thymidine kinase (TK), 10 substrates are known along with their docked X-ray structures. The corresponding binding pockets differ among each other in their orientations of certain side-chains. We report attempts to include side-chain flexibility to our docking tool FlexScreen while screening the substrates against a database of 10000 ligands.

We demonstrate the optimization of siRNA transfection process for time and costs in a high throughput application with two independent measurements of the RNAi effect: The visual monitoring of Eg5 expression and the quantitative PCR measurement of GAPDH mRNA after transfection of Hela cells. The results show, that 1 wash cycle is sufficient for the removal of any remnants of the transfection complex from disposable tips, making the tips re-usable.

Transcreener™ KINASE ASSAY kits are far-red competitive fluorescence polarization immunoassays based on the detection of ADP. Any enzymatic reaction that uses ATP in a range from 1-250 µM can be monitored. With its dual emission detection and five photomultiplier tubes, BMG LABTECH´s PHERAstar provides the speed and sensitivity needed to take full advantage of BellBrook Labs Transcreener™ technology. Furthermore, a specific optical module was developed, thereby making assay setup simple.

The Bradford Assay is a fast and homogeneous assay to determine the protein concentration of samples. The shift of the dye can be followed with the new spectrometer tool. The FLUOstar Omega offers entirely new possibilities with its spectrometer. A whole absorbance spectrum can be read in about 1 sec per well. The speed of the spectrometer and the easy work-up in the software provide users with unmatched flexibility.