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Latest Posters
Functional Characterization of the Human Fractalkine Receptor CX3CR1 Using Photina™, a new Highly Sensitive Photoprotein
Poster

Functional Characterization of the Human Fractalkine Receptor CX3CR1 Using Photina™, a new Highly Sensitive Photoprotein

CX3CR1 has been stably transfected into CHOmitoPhotina™- MRE-CRE-Luciferase cell line and assays suitable for HTS and uHTS have been developed.
GPVI-RBL-2H3-NFAT-Re Luciferase Cell Line: a New Cell Based System for Studying Collagen Receptor Activation
Poster

GPVI-RBL-2H3-NFAT-Re Luciferase Cell Line: a New Cell Based System for Studying Collagen Receptor Activation

This study describes the generation of a cell based assay which allows the functional characterization of the human GPVI receptor, by the use ofluminescence.
High Density Receptor Ligand Binding Assays in the MultiScreen®HTS 384-well Glass Fiber Filter Plate
Poster

High Density Receptor Ligand Binding Assays in the MultiScreen®HTS 384-well Glass Fiber Filter Plate

Using the Muscarinic M1 G-protein Coupled Receptor as a model system, we achieved accurate and reproducible determinations of binding affinity (Kd) and IC50 results for known ligands on the 384-well plate device. As a result of being able to incubate the reaction mixture in the filter plate and configure the assay using half the reaction volume, significant reductions in reagent costs and radioactive waste were achieved.
Screening of Biologically Active Natural Products in PIBOC
Poster

Screening of Biologically Active Natural Products in PIBOC

We screen natural products for antimicrobial, antiviral and anticancer activity, immunomodulatory effects, as inhibitors of cell adhesion and antioxidants. High resolution MRI-tomography with 7T magnet (PharmaScan 70/16US, Bruker) allows us to search in situ for compounds with anticancer, anti stroke and anti ischemia activity, inhibitors of angiogenesis and hepatoprotective substances.

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