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High-density screening platforms are an integral part of any successful high-throughput screening facility. The reduced assay volumes associated with increasing well density lowers reagent costs, accelerates assay throughput, and can improve assay quality and reproducibility by minimizing assay duration.

Application of microarrays during process development helps to gain insight in biological processes involved in product formation, increasing process understanding.

An investigation on the plasma and urine samples of healthy male volunteers designed to evaluate the variability in metabonomic data, when severe life-style and dietary restrictions are imposed.

The aim of our study was to analyze the antiproliferative activity effects on human tumor cell lines and the differentiating activity on human erythroleukemic K562 cells of different extracts derived from medicinal plants of Bangladesh and Lebanon.

The novel Lewis acid catalyzed condensation of aldehydes with 3-alkyl-1-methyl-thioxo-imidazolidin-4-ones (thiohydantoins) to generate the corresponding (E)/(Z) 5-arylidene-3-alkyl-1-methyl-2-thioxo-imidazolidin-4-ones (arylidene thiohydantoins) is presented. A survey of various catalysts was conducted (either indium(III) triflate, aluminum trichloride, or boron trifluoride diethyl etherate) and compared with the uncatalyzed reactions.

Acyl glucuronides are key phase 2 metabolites for many carboxylic acid-containing drugs, notably of non-steroidal anti-inflammatory agents (NSAIDs).1 It is important to synthesise acyl glucuronides in pure form, and especially as single 1ß-anomers, for bioevaluation during drug discovery and development. Acyl glucuronides are reactive species: they may react by hydrolysis or displacement with other nucleophiles or by acyl migration followed by condensation with amines.

The development of multiplexing capabilities and high content readouts reporting individual cellular measurements enables assessment of biological variability on a single cell basis. A multiplexed high content screening (HCS) assay allows additional information to be gained from a single assay.

Multicolor quantum dot probes emitting from 525 to 705 nm can be effectively excited with a single 488 nm laser, resulting in signals equal to the best organic dyes, but that are cleanly discriminated with simple color filters. Using a plate based 4-color laser scanning system with a single 488 or 405 nm laser for excitation, we have detected the binding of quantum dot conjugates to CD45 on human monocytes.

In this study we have used high-resolution genome-wide DNA copy number screening by array-based comparative genomic hybridization (array CGH)2-3 to identify the underlying genetic cause of this malformation syndrome. Through this screening we identified overlapping microdeletions on chromosome 8 in two CHARGE patients.

The Honeybee 963 for automated sitting drop crystallization studies enables rapid, precise and accurate dispensing of nano-liter (nl) volumes of screening and protein solutions. Rapid dispensing to both reservoirs and shelves minimizes evaporation while precise and accurate dispensing allows for miniaturization and conserves precious protein.