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Latest Posters

High-Throughput Automation of a Dual Reporter Assay in Low Volume 384 & 1536 Well Plate Formats  content piece image
Poster

High-Throughput Automation of a Dual Reporter Assay in Low Volume 384 & 1536 Well Plate Formats

The drive towards miniaturization within the pharmaceutical and biotechnology fields has created a need for liquid handling technologies that accurately deliver low volume reagents to high-density plates. This has also created a need for simple, fully scaleable assays in low volumes. Here we demonstrate the successful combination of both through the use of the Equator™ NS 808 - Eight Tip Pipetting System and the dual color Chroma-Luc™ technology.
Miniaturisation of Liquid Handling Procedures for High Throughput Sequencing  content piece image
Poster

Miniaturisation of Liquid Handling Procedures for High Throughput Sequencing

Deerac Fluidics Equator™ products are designed to fit a wide range of applications requiring low volume liquid handling. The products have recently been installed as part of the high throughput sequencing production process at the Broad Institute in Boston, MA, USA. This poster will describe the current process employed by Broad Institute, highlighting where the Equator™ has played a vital role in performance enhancement and cost reduction, enabling the Broad Institute to retain its position as
Software for Automated Differential Expression Using 2D and 3D Representations of LC-MS Data Interactive Confirmation of Results content piece image
Poster

Software for Automated Differential Expression Using 2D and 3D Representations of LC-MS Data Interactive Confirmation of Results

DeCyder™ MS is a novel software program for fully automated differential expression analysis based on LC-MS/MS data including detection, quantitation, sample to sample comparison and statistical data evaluation. Results can be interactively confirmed against original raw data through 2D and 3D data visualizations.
The Use of Software Visualization Tools for the Identification of PTM Patterns and Artefacts in LC-MS Experiments content piece image
Poster

The Use of Software Visualization Tools for the Identification of PTM Patterns and Artefacts in LC-MS Experiments

By representing LC-MS data as a 2D-image as demonstrated in the novel DeCyder™ MS software, it is possible to identify phenomena, which are very difficult to recognize using conventional LC-MS data representation.
Sensitive Identification of Phosphopeptides in Brain Tissue using 2D-NanoLC-ESI-MS<sup>n</sup> content piece image
Poster

Sensitive Identification of Phosphopeptides in Brain Tissue using 2D-NanoLC-ESI-MSn

In this work, a biocompatible nano liquid chromatography (LC) system, Ettan™ MDLC, was used for separating tryptic peptides from brain tissue by cation exchange (SCX) to enrich the phosphopeptides followed by reversed-phase chromatography (RPC). The phosphopeptides were detected by neutral loss MS.
IGF1 Biomarker Assay Validation content piece image
Poster

IGF1 Biomarker Assay Validation

This work demonstrates the development and validation of a novel clinical proteomics approach in which specific protein targets can be expeditiously and selectively isolated from acomplex biological fluid for MS characterization.
Addressing the Repoducibility Aspect of LC-MS Based Protein Identification  content piece image
Poster

Addressing the Repoducibility Aspect of LC-MS Based Protein Identification

By using the detection, matching, and visualization approach ofDeCyder™ MS were retention time, precursor mass, and the topology of the intensity profile is utilized in combination with the matching of tandem mass spectra, it is possible to achieve repeat analysis with a very high reproducibility.
Functional Characterization of the Human Fractalkine Receptor CX3CR1 Using Photina™, a new Highly Sensitive Photoprotein content piece image
Poster

Functional Characterization of the Human Fractalkine Receptor CX3CR1 Using Photina™, a new Highly Sensitive Photoprotein

CX3CR1 has been stably transfected into CHOmitoPhotina™- MRE-CRE-Luciferase cell line and assays suitable for HTS and uHTS have been developed.
GPVI-RBL-2H3-NFAT-Re Luciferase Cell Line: a New Cell Based System for Studying Collagen Receptor Activation content piece image
Poster

GPVI-RBL-2H3-NFAT-Re Luciferase Cell Line: a New Cell Based System for Studying Collagen Receptor Activation

This study describes the generation of a cell based assay which allows the functional characterization of the human GPVI receptor, by the use ofluminescence.
High Density Receptor Ligand Binding Assays in the MultiScreen®HTS 384-well Glass Fiber Filter Plate content piece image
Poster

High Density Receptor Ligand Binding Assays in the MultiScreen®HTS 384-well Glass Fiber Filter Plate

Using the Muscarinic M1 G-protein Coupled Receptor as a model system, we achieved accurate and reproducible determinations of binding affinity (Kd) and IC50 results for known ligands on the 384-well plate device. As a result of being able to incubate the reaction mixture in the filter plate and configure the assay using half the reaction volume, significant reductions in reagent costs and radioactive waste were achieved.
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