Latest Posters
Poster
Design of a modularized, intensified milli-reactor for production scale
Results of a model based design of an exemplary chemical reaction in a production scale Miprowa® are presented, allowing for a considerable evaluation and classification of the reactor’s performance.
Poster
The Impact of MRI on Genitourinary and Gastrointestinal Toxicity after Radiation Therapy
MRI has several advantages relative to other imaging modalities in evaluating, diagnosing, and planning treatment for prostate cancer. However, it is rarely ordered for localized disease. While the diagnostic abilities have been studied, little has been done to associate clinical outcomes with prostate cancer patients who received MRI.
Poster
Monitoring Cell Health in Real-time / Time-lapse Cell-based Assays
The purpose here is to validate a novel far-red DNA binding viability probe, DRAQ7™, in real-time cell based assays for 2-D and 3-D models.
Poster
GALAS Modeling Methodology Applications In The Prediction Of Drug Metabolism Related Properties
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task and is performed only at the later phases of drug development. Therefore the possibility to predict possible sites of human liver microsomal (HLM) metabolism using in silico techniques would be a very attractive feature for any medicinal chemist.
Poster
Modulation of GPRC6A Signaling to Mitigate Tauopathies
Overall, our data suggest that decreased GPRC6A signaling reduces tau pathology. Further studies is required to warrant the role of GPRC6A in amino acid sensing associated autophagy or other protein degradation mechanisms. GPRC6A allosteric antagonists may potentially find utility as novel drugs to treat tauopathies and related disorders.
Poster
Change in pattern of secondary malignancies following Kaposi's sarcoma in the era of anti-retroviral therapy
This study hypothesis is that the secondary cancers that develop in patients with KS have changed.
Poster
Pharmacological Ascorbic Acid and Hyperbaric Oxygen Therapy Target Tumor Cell Metabolism via an Oxidative Stress Mechanism
This data indicates that AA exhibits anti-cancer effects in vitro through an OxS mechanism and that HBOT can enhance this therapeutic effect.
Poster
Amyloid Beta Nano Particle used to Sensitize Dendritic Cells as a Therapeutic Vaccine against Alzheimer's disease
This project researches the use of immunotherapy to combat Alzheimer's disease. This is achieved by exposing dendritic cells, antigen presenting cells, to amyloid beta in order to sensitize the cell. The results indicate that a mutant form of amyloid beta was successful in producing anti-amyloid-beta antibodies and in improving behavior in the mice.
Poster
Neuronal Mislocalization of Mutant DHHC9 in X-Linked Intellectual DIsability
DHHC9 is a protein acyltransferase (PAT) that adds a palmitate to specific protein substrates. In the neuron, palmitoylation of various proteins by DHHC9 facilitates proper neuronal function. Recently, a DHHC9 nonsense mutation (R298*), resulting in a truncation of the last 67 amino acids of the protein, has been associated with X-Linked Intellectual Disability (XLID). Here, we compare neuronal localization of the wild-type (WT) and R298* mutant DHHC9.
Poster
Cell X and Colonyze Platform for Cell Sourcing and Process Controls
Cleveland Clinic and Parker Hannifin have collaborated to create the Cell X and Colonyze platform as resource tools for cell source management and quality control.
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