Latest Posters
Poster
An Antitumor Antibody Response to Attenuate Metastatic Melanoma in a Murine Model
These preliminary results show antitumor activity of adoptive cell transfer of MHC class mismatched CD4(+) T-cells. The finding of reduced numbers of pulmonary metastases correlates with increased serum anti-OVA IgG and increased germinal center development in the spleen.
Poster
Activation of PTEN lipid phosphatase function in lung cancer
We have discovered novel small molecule compounds that directly induce PTEN function and antagonize PI3K/AKT pathway activity in lung cancer cells.
Poster
Isolated Limb Infusion as a Limb Salvage Strategy for Locally Advanced Extremity Sarcoma
We review perioperative and oncological outcomes and compare survival between ILI and amputation.
Poster
Optogenetics on FDSS7000EX: Light-stimulated membrane depolarization in cultured cells expressing channelrhodopsin using a kinetic plate reader
The aim of this study was to establish clonal cell lines stably expressing a channelrhodopsin variant and measure membrane potential changes with a fluorescent dye induced by repetitive light-stimulations in a 96-well plate on a kinetic plate reader FDSS 7000EX.
Poster
Rare Diagnosis of Malignant Mesothelioma in a Young Patient with Rheumatoid Arthritis
This is a rare presentation of malignant pleural mesothelioma in a young female patient with rheumatoid arthritis and no known asbestos exposure.
Poster
Onchocerca Diagnostic Testing of Polymorphisms; Effects of Antigenic Mutations on Detection of Antibodies by OV-16 ELISA
Here, we have identified the particular polymorphism responsible for the loss of monoclonal antibody reactivity and investigated the potential effect these polymorphisms may have on the sensitivity of the Ov16 ELISA for the detection of parasite exposure.
Poster
Cross-disciplinary Optimization of Nano-Drug Delivery to Ovarian Carcinoma and Glioma Cells
This study reports on the quantitative analysis of the diffusion and localization of a targeted drug delivery system (DDS) consisting of fluorescent labeled 0.01 µM paclitaxel-BODIPY 564/570 encapsulated in non-ionic surfactant vesicles embedded in a thermosensitive cross-linked chitosan hydrogel.
Poster
Hexachlorophene reduces Tau aggregation and potential therapeutic agent for treatment of Alzheimer’s disease
An increase in phosphorylation of tau (hyper phosphorylation) leads to aggregation of the protein resulting in neurofibrillary tangles, a pathological hallmark associated with Alzheimer’s disease (AD). The identification of pharmacological agents that can help decrease levels of phosphorylated tau would be advantageous. Recent work in our laboratory has found that the molecule hexachlorophene can regulate levels of tau in cellular models.
Poster
Astaxanthin Attenuates Neurotoxicity in a Mouse Model of Parkinson’s disease
Both oxidative stress and inflammation are involved in the progression of many neurodegenerative diseases, therefore, we examined the potential for AXT to reduced neurotoxicity in a toxic model of PD in mice. Here, we show that administration of algae derived AXT mitigated MPTP induced dopamine cell death.
Poster
Discrepancy between TRPA1 Activation by Reversible and Irreversible Electrophiles Suggests Involvement of Cytosolic Cofactors Other Than Polyphosphates
Electrophiles can bind through reversible or irreversible reactions based on the structure of the compound. Here, patch clamp techniques and calcium imaging have been used to characterize human TRPA1 (hTRPA1) channel activity (expressed in HEK293 cells) in the presence of reversible and irreversible electrophiles
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