2D FT-ICR MS/MS Analysis of lgG1
Poster Sep 10, 2019
Johanna Paris, Tomos E. Morgan, Yuko P.Y. Lam, Christopher A. Wootton, Mark André Delsuc, Mark P. Barrow, John O’Hara, Peter B. O’Connor
Recombinant monoclonal antibodies and derivatives are widely used as therapeutic drugs. Post-translational modifications during the manufacturing process and storage can result in product-related impurities. PTMs can change the efficacy, toxicity, or the clearance of the antibody; therefore they need to be well monitored.
Download this poster to learn how you can achieve 2D FT-ICR MS/MS analysis of IgG1 that includes:
- Effective analysis of bottom-up mixtures.
- Selectively analyzes phosphopeptides.
- A new approach to top-down proteomics.
- An alternative to MS/MS.