3D-Tissue/ Whole-blood Co-culture Models Combined with Multi-Analyte Profile (MAP) Analyses for In-vivo-like Immunopharmacology
The effect of drugs on such omplex regulation can be analysed reliably only in an environment that represents the complexity of such feedback systems. HOT Screen GmbH developed a series of proprietary human organotypic co-culture test systems combining whole-blood cultures with cultures of differentiated intestinal epithelia, 3D epidermis, bronchial epithelia, etc. These allow to study drug effects on immunoregulation even in in-vivo-like human inflamed tissue environments.
Multiplexed Luminex® assays (MAP tests, MyriadRBM) were used as complex readouts when testing drug effects on cell activation.