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Traditionally, there has been a compromise between performance and sustainability.

The NovaSeq X Plus system enables sequencing of >20,000 genomes per year and delivers data in half the time with a 2.5x improvement in throughput. Breakthrough advancement in chemistry, optics and software contribute to fast, highly accurate and cost-effective data.

Researchers looking to answer complex biological questions often require increased statistical power, larger studies and deeper sequencing methods.

In tumors, metabolic shifts cause increased glucose uptake and fermentation. Traditionally, bulk analysis has been used to measure tumor metabolism, however, all tumors show some heterogeneity, and only an average measurement is produced by bulk analysis.

In a normal immune response, entry of the SARS-CoV-2 virus into lung tissue induces controlled activation of the immune system.

Highly multiplexed spatial biomarker analysis has demonstrated the potential to advance our current understanding of the immune system and its role in cancer.

Environmental chemicals have the potential to perturb hormone systems, a finding that has led to recommendations for the testing of potential endocrine disrupting chemicals.

T cells can develop an exhausted phenotype due to prolonged antigen stimulation, resulting in reduced proliferative potential and loss of cytotoxic funtion. This can occur within the tumor microenvironment, allowing cancer cells to escape immune surveillance.

The hypothalamic-pituitary-thyroid axis (HPT axis) is conserved across vertebrate evolution. Perturbation of thyroid hormone homeostasis (THH) can lead to adverse effects in thyroid function affecting growth, metabolism and cognitive function.

Insights and Expanding Practical Education in a Core Facility With Brightfield Imaging-Enabled Flow Cytometry

The growing use of RNA-based vaccines and therapies has focused much attention and effort on developing conditions for maximizing the yield and efficiency of the in vitro transcription (IVT) reactions used to produce mRNA. IVT procedures involve the biosynthesis of RNA from a linear DNA template containing an appropriate transcription promoter. But how do different buffer conditions and nucleotide concentrations impact the IVT reaction?