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To overcome these challenges, researchers have developed a proprietary gene-expression targeting strategy that can rapidly reprogram hiPSCs into pure somatic cell types in a scalable manner. This approach was used to develop a Huntington’s disease (HD) model carrying a 50CAG expansion in the huntingtin (HTT) gene.

Researchers require spatial information and high-plex gene expression data to understand how cells interact with tumors. However, molecular subtyping within a tumor type requires additional stratification at the tissue level to facilitate meaningful subsequent gene expression analysis.

Traditionally, there has been a compromise between performance and sustainability.

Researchers looking to answer complex biological questions often require increased statistical power, larger studies and deeper sequencing methods.

In tumors, metabolic shifts cause increased glucose uptake and fermentation. Traditionally, bulk analysis has been used to measure tumor metabolism, however, all tumors show some heterogeneity, and only an average measurement is produced by bulk analysis.

In a normal immune response, entry of the SARS-CoV-2 virus into lung tissue induces controlled activation of the immune system.

Highly multiplexed spatial biomarker analysis has demonstrated the potential to advance our current understanding of the immune system and its role in cancer.

Environmental chemicals have the potential to perturb hormone systems, a finding that has led to recommendations for the testing of potential endocrine disrupting chemicals.

T cells can develop an exhausted phenotype due to prolonged antigen stimulation, resulting in reduced proliferative potential and loss of cytotoxic funtion. This can occur within the tumor microenvironment, allowing cancer cells to escape immune surveillance.

The hypothalamic-pituitary-thyroid axis (HPT axis) is conserved across vertebrate evolution. Perturbation of thyroid hormone homeostasis (THH) can lead to adverse effects in thyroid function affecting growth, metabolism and cognitive function.