Latest Posters
Poster
Automation of a Generic Fluorescence Methyltransferase Activity Assay
Epigenetic processes are attracting considerable attention in drug discovery as their fundamental roles in controlling normal cell development and contributions to disease states become more clearly defined. This work combines a fluorescence-based assay with liquid handling and dispensing instrumentation and a multi-mode reader which can be used to monitor the biological activity of the histone methyltransferase (HMT) G9a, a model system.
Poster
Validation of an Automated Cell-Based Bioluminescent TNFa Blocker Bioassay
TNFa blocker biopharmaceuticals represent an important and successful class of protein drugs used in the treatment of several autoimmune diseases. Bioassays are indispensible tools in biopharmaceutical drug development and commercialization that are used to quantify biological activity and stability of drugs or drug candidates. The automation of these assays can serve to create an accurate, robust process which can allow the researcher to perform other more important functions.
Poster
Automated Solutions for Cellular Screening and Characterization of Therapeutic Antibodies for Antibody-Dependent Cellular Cytotoxicity Utility
Since the end of the 1990’s, the pharmaceutical industry has seen an increased interest in biologics, especially in the therapeutic areas of oncology and inflammation. Here we present the automation of two assays for the characterization and selection of potent antibody drug candidates. Both assays rely on HTRF® detection. The first assay quantifies the binding affinity of antibodies to their target antigen, on live cells.
Poster
An Automated, Cell-based Platform for the Rapid Detection of Novel Androgen Receptor Modulators
The Androgen Receptor (AR) is a member of the family of nuclear receptors responsive to steroid hormones. This poster aims to devise, validate and perform a preliminary automated HTS screening campaign to identify novel modulators of AR activity.
Poster
A Simple, Robust Automated Multiplexed Cell-Based Assay Process for the Assessment of Mitochondrial Dysfunction and Cytotoxicity
Recent studies have shown that an increasing number of drugs no longer on the market have negative effects on mitochondrial function in key organs such as the liver and heart. Therefore it is increasingly important to monitor the effects of lead compounds on mitochondrial function in relevant cell systems. The ability to incorporate a simple, rapid, multiplexed, predictive assay can make the detection of potential toxic effects easier to perform early on in the drug discovery process.
Poster
Screening for Optimal Algal Cell Growth and Neutral Lipid Production Conditions in Microplates
Algae based products offer many potential advantages over food based sources of energy, however significant research is still required in order to make them an economically viable option. To date, algal research has not extensively utilized the tool of high throughput screening using microplates that has been successfully employed in fields such as drug discovery.
Poster
Modular Bench Top Automation
ELISA is one the most utilized assay formats in biomedical research. Numerous clinical, veterinary, and research assays use the specificity of antibodies to identify a diverse array of analytes from any number of different matrices. This poster details a modular bench top workstation capable of automating the assay process steps of most conventional ELISA assays.
Poster
Expression of Pluripotency-determining Factors in in vitro Fertilized Buffalo Embryos and Embryonic Stem Cells
The POU octamer-binding domain transcription factor Oct-4, Stage-specific embryonic antigens (SSEAs), and Tumor rejection antigens (TRAs), are developmentally regulated during early embryogenesis.
Poster
Antibacterial Activity of Silver Nanoparticles Obtained by Electrochemical Synthesis in Poly(Amide-Hydroxyurethane) Media
Due to the outbreak of the infectious diseases caused by pathogenic bacteria, inorganic nanoparticles (NPs) have emerged up as novel antimicrobial agents.
Poster
In Silico Identification of Conserved Domains from EST Database in Safflower
Identified conserved domains or gene families from the ESTs could be utilised for the identification of gene-targeted markers and for development of functional markers to accelerate marker assisted backcross breeding in safflower.
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