Latest Posters
Poster
Effect of Culture Media and Serum Supplementation on the Development of in vitro Fertilized Buffalo Embryos
This poster compares the development of buffalo embryos in simple and complex culture media and aims to determine the effects of serum supplementation on the development of buffalo embryos.
Poster
Antigen Determination in Autoimmune Hepatitis Type1
Objectives of this project were to exploit the database in indian setting to determine nuclear antigens as target for antinuclear antibodies (ANA) in patients of autoimmune hapatitis (AIH) type1.
Poster
Nanoliter Volume Pin Tool Transfers as Measured by a Dual-Dye Absorbance Method
This poster compares the volumes of sample solutions delivered by an array of stainless steel and hydrophobic-coated pins as measured by a fluorescent-dye approach versus a dual-dye absorbance approach.
Poster
Ion Chromatography ICP-Q-MS for the Detection of Arsenic Species in Apple Juice
Interest in the determination of Arsenic species in fruit juices has been triggered by recent media reports in the United States claiming that some apple juices may contain high amounts of Arsenic. Inorganic forms of Arsenic (As3+ and As5+) are highly toxic, whereas the organic forms (e.g. arsenobetaine) are not considered toxic. A robust IC-ICP-MS system was developed and shown to be a highly selective and sensitive technique for determination of trace element species.
Poster
High Content Analysis of Neural Stem Cell Expansion and Differentiation
Automated assay methods for monitoring neural stem cell expansion and differentiation using stem cell derived neural cell lines and high content imaging systems have been described.
Poster
Modeling Disposition of Sotalol following Intravenous and Oral Administration in Healthy Adult Subjects
Sotalol is a non specific adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmia. Its absorption, distribution and systemic PK or, collectively, ‘disposition’ was modeled and simulated using GastroPlus™ v7.0. Biopharmaceutical properties were obtained from in silico predictions and in vitro measurements.
Poster
Predicting hERG Potassium Channel Affinity with Artificial Neural Network Ensembles
Modeling hERG inhibition has gained significant popularity since 2005, when the FDA recognized the correlation between hERG inhibition and a prolonged QT interval by issuing guidance for the evaluation of new non-antiarrythmic drugs against the hERG channel.Long QT syndrome or LQTS is a risk factor for ventricular tachyarrhythmias and sudden death.
Poster
Predicting Sites of Metabolism with Artificial Neural Network Ensembles
Hepatic first-pass metabolism of many drugs and pro drugs plays a key role in their oral bioavailability. The human cytochrome P450 enzymes are responsible for the metabolism of most drugs. Knowledge of likely sites of metabolic attack in a drug molecule can aid in designing out unwanted metabolic liabilities early on in the drug discovery process, as well as in the design of pro drugs where metabolic transformation is desired.
Poster
Be Careful What You Ask for: Challenges of Predicting Human Clearance for a Low Metabolic Turnover Compound, ELND006
A study of in vitro clearance of ELND006, a low turn-over compound.
Poster
A Long Term Culture Model for Primary Hepatocytes from Cynomolgus Monkeys
The Macaca fascicularis or cynomolgus monkey is a non-human primate often used in pre-clinical animal studies. In this study, we applied microtechnology and tissue engineering techniques to cynomologus monkey hepatocytes in order to determine if these cells could be stabilized in micropatterned co-cultures similar to their human and rat counterparts.
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