Latest Posters
Poster
Visualizing the Dynamic Epigenome
A method is presented to visualize genome-wide information from epigenetic data. It is capable to integrate additional information. Applied to mouse data consisting of H3K4, H3K27, and H3K9 trimethylation for 3 different celltypes, the dynamic behavior and interplay was investigated.
Poster
miREC: A database of miRNAs involved in endometrial cancer
The miREC database integrates public data about miRNAs and their target genes involved in the development of EAC in human, collected from recent literature. In future versions the database will be complemented with information derived by analyzing our in-house data and new published data by other researchers. The miREC database is the first database that focuses on integrating all available information about genes and miRNAs involved in endometrial cancer.
Poster
A Weight-of-Evidence Approach to Prioritisation based on Consensus across Multiple Sources of Information
We present the results of initial work carried out within the OpenToxLink Virtual Organization, applying a Weight-of-Evidence (WoE) approach based on consensus across multiple sources of information for the prediction of adverse effects of a large set of potential antimalarial compounds. The work was carried out as part of the EU FP7 project SYNERGY, evaluating the support of decision dashboards and event-driven collaborative research of software developed within SYNERGY.
Poster
MicroRNA expression in normal and malignant prostate tissues
In this study the aim was to identify a miRNA expression signature that could be used to separate between normal and malignant prostate tissues. Nine miRNAs were found to be differentially expressed and they could be used to separate between the normal and malignant tissues. A cross-validation procedure confirmed the generality of this expression signature, showing an accuracy of 85%.
Poster
Point-of-Care Diagnostics for Sexually Transmitted Infections
This poster introduces the recently enlarged DoCLab research group at Brunel University, London. This large multidisciplinary group brings together electronic, mechanical and computer engineers with molecular biologists, biochemists and clinical collaborators to develop fully integrated, multiplex Point-Of-Care-Tests (POCT) for the self- diagnosis of infectious diseases.
Poster
Quercetin Accumulation is Associated with Drought Resistance in White Clover
White clover is an important pasture legume, but growth is often strongly reduced under summer drought. Abiotic stress is mediated by the induced production of flavonoids. At the individual genotype level, increased flavonol (quercetin) accumulation in response to water deficit stress is positively associated to retaining higher levels of dry matter production.
Poster
Three-dimensional quantitative structure-activity relationship analysis and ADME predictions of guanylhydrazone coactivator binding inhibitors of estrogen receptors
The estrogen receptors (ER) refer to a group of the nuclear hormone receptor superfamily of ligand-mediated transcriptional factors. Over expression of this type of receptors leads to a breast cancer progression. Hormone-responsive breast cancer develops resistance to conventional anti-cancer therapy, and this becomes a major problem in a breast cancer therapy.
Poster
Molecular dynamics of POPC and POPE lipid membrane bilayers enforced by an intercalated single-wall carbon nanotube
In this study, we used high temperature molecular dynamics simulation (400 K), because it is known that critical fluctuations of lipid membranes can even occur at 313 K and especially above 343 K the interlamellar water layer thickness starts to increase non-linearly due to "hydration force". We implemented this method to emphasize POPC and POPE (palmitoyl-oleoyl-phosphatidylethanolamine) membrane bilayer stability enhanced with single-wall carbon nanotube.
Poster
Regulation of shoot apical meristem development by SEUSS and SEUSS-LIKE 2 in Arabidopsis
In Arabidopsis, SEU and SLK2 are redundant components of a regulatory complex that is proposed to promote shoot apical meristem (SAM) formation during embryogenesis. Expression analysis indicates that SEU and SLK2 act upstream of several known SAM regulators, and also regulate auxin accumulation, probably via interaction with auxin response factors.
Poster
Novel Serological Assay Using HIgh-Throughput Chromogenic Microarray Technology for Screening SPF Non-human Primates
Routine surveillance programs to detect microbial agents in non-human primate colonies are critical to maintaining colony health and safety, as well as research integrity. Serological testing is a crucial element of maintaining colony health, but current methods rely on slow, expensive, and low-throughput ELISA-based serological assays. Here we describe the development of a sensitive, specific, robust, and easily automated method for colony health screening programs.
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