A fast and fully automated solution for Lipidic Cubic Phase (LCP) screening using mosquito LCP
Poster Jul 05, 2011
Joby Jenkins1, Patricia Edwards2, Rob Lewis1and Joanne Franklin1
Membrane proteins, such as G-protein-coupled receptors, are known to be much more difficult to purify and crystallise than soluble proteins due to their native environment within the lipid bilayer of the cell membrane. The in meso (lipidic cubic phase or LCP) crystallisation technique has revolutionised the process of crystallising membrane proteins. This method utilises highly viscous lipid mesophases to contain the membrane proteins for crystallisation.