A Modular Solution for Storage of Biological Samples
Poster Feb 28, 2008
Joby Jenkins, Wayne Bowen, Ben Schenker, Chloe Milburn
The physical and chemical composition of biological samples is more diverse than the libraries of medicinal compounds used for drug discovery research. Types of samples include proteins, nucleic acids, blood and serum samples, cell suspensions, tissue biopsies, and antibodies. Thus any storage system must be flexible to accommodate the differing storage requirements of each sample type base upon its biochemical composition, stability and where appropriate, solvent.
The comPOUND sample store (TTP LabTech) is a modular system that can be installed almost anywhere and offers a range of solutions from manual, front of store retrieval, through remote delivery, and walk away overnight processing. This fully scaleable approach to biological sample storage provides flexibility for different inventory sizes and allows storage capacity to increase in-line with sample acquisition.
comPOUND® provides a safe, efficient and flexible environment for the safe storage of biological samples.
We utilized paired synthetic crRNAs coupled with our synthetic tracrRNA in cells transduced with lentiviral Cas9 to perform a functional knockout on hsa-miR-221. This three-part system (crRNA, tracrRNA and Cas9) has demonstrated efficient gene editing when used with only one guide RNA, but the goal was to use two crRNAs to remove the entire stem-loop.READ MORE