A Systematic Review of Lifestyle Modification in Adults with Non-Alcoholic Fatty Liver Disease
Poster Apr 04, 2012
C. Thoma, C. P. Day and M. I. Trenell, Newcastle University
Non-alcoholic fatty liver disease is an independent risk factor for type 2 diabetes and cardiovascular disease that affects about 30% of the adult population. There is no approved pharmacotherapy, thus lifestyle modification is broadly advocated as a treatment. Prior to this review, there was no systematic assessment of the evidence base for making lifestyle change recommendation in this group of patients.
During early drug discovery, the study of metabolism plays an essential role in determining which drug candidates move forward into development and later stages. As an alternative to traditional Data Dependent Acquisition (DDA), the use of MSE/All Ions Fragmentation (AIF) has become common in metabolite identification workflows for the analysis of metabolic hot spots. Here we present a solution for analysis of MSE/AlF in metID studies.READ MORE