An Automated, Cell-based Platform for the Rapid Detection of Novel Androgen Receptor Modulators
Poster Feb 16, 2012
Brad Larson, Bruce Sherf (INDIGO Biosciences), and Peter Banks
AR activity is regulated through the binding of androgenic hormones (eg., testosterone and di-hydroxy testosterone). In turn, AR functions to regulate the expression of a myriad of genes involved in metabolic processes, cell proliferation/apoptosis, and male sexual differentiation and development. AR dysfunction often has severe health implications, such as androgen insensitivity syndrome and prostate cancer. Consequently, AR commands much attention as a target for the discovery and development of improved drugs. In particular, anti-androgens comprise an important class of drugs used in the treatment prostate cancer.