Analysis of Polymers, Additives and Contaminates in Medical Devices using Pyrolysis-GCMS
Poster Mar 04, 2015
Polymers and additives are used in a variety of subcutaneous and intravascular medical devices, such as sutures and drug delivery systems. These devices typically can be classified as being either absorbable or non-absorbable by the human body. Natural materials, such as silk and catgut, are largely being replaced by synthetic materials. So, the reliability of these devices relies on the quality and proper application of these synthetic compounds. But regardless of their composition, the materials used are foreign to human tissue and will elicit a foreign body reaction to a greater or lesser degree. This poster will show the analysis of several types of implanted medical devices from different manufacturers using pyrolysis-GCMS. Traditionally, pyrolysis has been used as a technique to identify polymers, which will be shown. But in addition, one or more "pre-pyrolysis" steps will be programmed first so that we can analyze for residual monomers, solvents, additives and contaminates, if present. Undesired contaminates or the incorrect quantity of an additive can often lead to product failure or worse.
Proteomics and Substrate Based MS Imaging of Xenobiotic Metabolising Enzymes in Ex Vivo Human Skin and a Human Living Skin Equivalent ModelPoster
Untargeted proteomics analysis showed that human skin and a commercially available living skin equivalent model exhibit a similar distribution of xenobiotic metabolising enzymes. A new technique, substrate based mass spectrometry imaging (SB-MSI) was developed during this study.READ MORE
Development and Assessment of Non-Infected and Infected Skin Models Using MALDI-MSIPoster
Infections have detrimental effects on wound healing leading to chronic wound formation. The use of labskin,a living skin model, in combination with mass spectrometry imaging, provides a good model for assessing wound healing factors.READ MORE
Overcoming the Challenges of Analysing Ionic Polar Pesticides in FoodPoster
Here, the novel application of the Waters’ Torus DEA column is presented, showing the improved performance of a UPLC-MS/MS method for the underivatised
analysis of glyphosate and a selection of other anionic pesticides.