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Antigen-Specific Delivery of siRNA Against Eucaryotic Elongation Factor 2 by Rationally Designed Bivalent Aptamer-siRNA Transcripts

Poster   Aug 17, 2007

 
Antigen-Specific Delivery of siRNA Against Eucaryotic Elongation Factor 2 by Rationally Designed Bivalent Aptamer-siRNA Transcripts
 
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nga Neef, Ulrich Wüllner, Andreas Eller, Michael Kleines, Rainer Fischer, Mehmet Kemal Tur and Stefan Barth

 
 

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License

 
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OTHER POSTERS

Detection of 17 Targets in a Single PCR Tube by a Novel MeltPlex® Probe System Combining Melting Curves and Taqman Probes

Poster

Despite the developments in conventional PCR, the complexity of multiplex Real Time PCR is still limited due to the lack of sufficient detection channels. To achieve high-end multiplexing capacity on standard Real Time PCR machines, Anapa Biotech has developed the MeltPlex® technology (see box on right).

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Characterization of a Type 2 diabetes-associated islet-specific enhancer cluster in STARD10 by genome editing of EndoC-βH1 cells

Poster

Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes. The majority of these are located in the intergenic or intragenic regions suggesting that the implicated variants may alter chromatin conformation. This, in turn, is likely to influence the expression of nearby or more remotely located genes to alter beta cell function. At present, however, detailed molecular and functional analyses are still lacking for most of these variants. We recently analysed one of these loci and mapped five causal variants in an islet-specific enhancer cluster within the STARD10 gene locus. Here, we aimed to understand how these causal variants influence b-cell function by alteration of the chromatin structure of enhancer cluster

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Psychiatric Risk Gene Cacna1c and Early Life Stress: Potential Gene-Environment interactions?

Poster

Early life stress (ELS) is highly associated with development of psychopathology
and mood disorders in adulthood. Genetic studies have identified variation in the gene calcium voltage-gated channel subunit alpha1C (CACNA1C) to increase risk for several psychiatric disorders. This poster assessed the expression of Cacna1c following prepubertal stress.

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