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Applications of EFC-based Protein-Protein Interaction Assays for Gi, Gs, and Gq-Coupled GPCR Screening

Poster

Published: December 13, 2007

Applications of EFC-based Protein-Protein Interaction Assays for Gi, Gs, and Gq-Coupled GPCR Screening content piece image

GPCR targets can be addresssed with a variety of technologies and they are increasingly being evaluated with multiple assay approaches. DiscoveRx has validated over 60 GPCR targets (Gi, Gs, Gq, Type A & Type B) in a novel generic cell-based assay format utilizing protein-protein interaction batween the GPCR C-terminus and b-arrestin2. Data outlining benefits provided for primary & secondary screening is presented.