Association between asthma-related emergency department visits, meteorological measurements, and air quality concentrations in the Bronx (2001-2008)
Poster Feb 21, 2015
Abraham R(1), Toh J(2), Desai T(2), Shum M(3), Patel P(2), Rosenstreich D(2), Jariwala SP(2)
Methods: We previously investigated AREDV at two Bronx hospitals (Montefiore-Weiler and Moses) from 1/2001 to 12/2008, and found that a spring increase in AREDV closely correlated with high tree pollen counts. In this study we analyzed the association between AREDV and other indices of air quality including pollutants (nitrogen dioxide-NO2, sulfur dioxide-SO2) and meteorological factors (precipitation, atmospheric pressure, humidity, temperature). Daily AREDV numbers were obtained through the CLG software. Daily counts for pollutants and meteorological variables were obtained through the National Climatic Data Center. Data were statistically analyzed and graphed as daily values.
Results: From 2001-2008, there were a total of 42,065 AREDV at the two hospitals. We consistently observed three distinct peaks of AREDV: January (winter), May (spring), and November (fall). The winter peak of AREDV correlated with increased NO2 and increased SO2. High precipitation levels in the fall closely associated with the fall peak of AREDV. We did not observe an association between atmospheric pressure or humidity and AREDV. High temperatures in the summer were associated with decreased AREDV.
Conclusions: There is a consistent association between the winter peak of AREDV and increased winter NO2 and SO2 concentrations. Increased precipitation closely associated with the fall peak of AREDV. These findings may help to predict periods of increased asthma exacerbations, although multivariate and prospective analyses are necessary.
Characterization of a Type 2 diabetes-associated islet-specific enhancer cluster in STARD10 by genome editing of EndoC-βH1 cellsPoster
Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes. The majority of these are located in the intergenic or intragenic regions suggesting that the implicated variants may alter chromatin conformation. This, in turn, is likely to influence the expression of nearby or more remotely located genes to alter beta cell function. At present, however, detailed molecular and functional analyses are still lacking for most of these variants. We recently analysed one of these loci and mapped five causal variants in an islet-specific enhancer cluster within the STARD10 gene locus. Here, we aimed to understand how these causal variants influence b-cell function by alteration of the chromatin structure of enhancer clusterREAD MORE
Treatment Options for Chronic Parvovirus Viremia in Pediatric Heart Transplant Patients in a Tertiary Care CenterPoster
This abstract discusses three cases of pediatric heart transplant patients who suffered from parvovirus (B19) infection. Of these patients, two ( B & C) responded well to standard intravenous Ig therapy. Patient A however, did not respond to standard treatment and was begun on subcutaneous Ig, which effectively diminished his viral load. Thus, subcutaneous Ig infusions might serve as a second line treatment for transplant patients with parvovirus who do not respond well to the standard approach.READ MORE
T-helper cell phenotype expression in cutaneous lesions of angioimmunoblastic T-cell lymphomaPoster
Angioimmunoblastic T-cell lymphoma (AITL) is a common type of peripheral T-cell lymphoma. AITL can be missed until lymphadenopathy develops in patients initially presenting with skin lesions, as skin biopsy may lack conclusive findings. Our case highlights the extranodal presentation of AITL with cutaneous lesions displaying the TFH phenotype.READ MORE