Automated detection and control of controlled substances
Poster Jan 26, 2015
Joe Bradley, Ian Johns
Chemical and pharmaceutical companies routinely work with controlled substances, and must have adequate controls in place to meet the rapidly changing legislative requirements of the countries in which they operate.
This legislation is becoming increasingly complex and changes frequently as legislators try to keep up with emerging “legal highs”. Meanwhile, externalization of R&D means that compounds are synthesised, stored and transported across a multiplicity of geographies with differing laws.
In 2013 Scitegrity, in conjunction with the Pistoia Alliance and a number of pharmaceutical companies, developed Controlled Substances Squared (CS2) to address this challenge.
The system is able to scan large chemical libraries (millions of compounds) and determine whether a compound is considered as controlled in a country and what controls are needed.
We found a distinct subpopulation of Tregs within BMSCs. Tregs and BMSCs in co-culture conferred neuroprotection that varied in a dose-dependent manner. Tregs minimized stem cell production of IL-6, a pro-inflammatory cytokine, and inhibited BMSC secretion of FGF-beta, a cytokine related to BMSC proliferation and differentiation. The ratio of Tregs found natively in BMSCs is optimally adapted to provide the maximum neuroprotective benefit of stem cell treatment after ischemic stroke.READ MORE