Automated Solutions for Cellular Screening and Characterization of Therapeutic Antibodies for Antibody-Dependent Cellular Cytotoxicity Utility
Poster Feb 16, 2012
Brad Larson, Peter Banks , Nicolas Pierre, Stéphane Martinez, and Francois Degorce
Since the end of the 1990’s, the pharmaceutical industry has seen an increased interest in biologics, especially in the therapeutic areas of oncology and inflammation. The selection of potent and selective Mabs (monoclonal antibodies) for specific target receptors, such as Receptor Tyrosine Kinase (RTK) and G protein-coupled receptors (GPCRs), is the first step in successfully developing an antibody based drug. In addition to potent binding, some antibodies have the ability to recruit the immune system effector cells, a process known as ADCC (Antibody Dependent Cell Cytotoxicity). The ability to promote ADCC is an important attribute of successful candidates and for that reason should be sought in the final drug design.