Bi-functional Magnetic Microcarriers for Point-of-Care Diagnostics
Poster Jun 27, 2011
J.J. Palfreyman, D.M. Love, A.J. Philpott, K. Vyas, T. Mitrelias, C.H.W. Barnes
A novel type of microcarrier is presented, where a re-writable magnetic barcode is used to carry information. This technology has several advantages over the optical-based alternatives, whilst benefiting from the high-throughput of a microfluidic tool. Here, we present two different surface chemistries used to attach a probe and a control strand of DNA to an individual microcarrier. This is demonstrated with red and green fluorophores, clearly seen on either side.
The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are closely related transcription factors that regulate the expression of phase I (cytochrome P450s), phase II metabolizing enzymes and transporter genes in response to xenobiotics, including prescription drugs.READ MORE