Biomass and Quercetin Accumulation Predict Drought Sensitivity in a Novel White Clover Hybrid
Poster Dec 04, 2009
This study shows for the first time that drought resistance in a new white clover hybrid can be linked to drought-induced increases in quercetin levels, and quercetin-to-kaempferol ratio levels. Subsequent DNA-marker analysis studies will be used to identify quantitative trait loci (QTL) for improved drought resistance in white clover to combine high Q response with high herbage yield.
Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes. The majority of these are located in the intergenic or intragenic regions suggesting that the implicated variants may alter chromatin conformation. This, in turn, is likely to influence the expression of nearby or more remotely located genes to alter beta cell function. At present, however, detailed molecular and functional analyses are still lacking for most of these variants. We recently analysed one of these loci and mapped five causal variants in an islet-specific enhancer cluster within the STARD10 gene locus. Here, we aimed to understand how these causal variants influence b-cell function by alteration of the chromatin structure of enhancer clusterREAD MORE
Early life stress (ELS) is highly associated with development of psychopathology
and mood disorders in adulthood. Genetic studies have identified variation in the gene calcium voltage-gated channel subunit alpha1C (CACNA1C) to increase risk for several psychiatric disorders. This poster assessed the expression of Cacna1c following prepubertal stress.