Biosensors using Surface Plasmon Resonance Dynamic Imaging
Poster Nov 10, 2006
J. Hottin, J. Spadavecchia, M. Canva, E. Maillart, M. Anger-Leroy and P. Kerourédan
We study the optical response of a SPRi detection system, characterizing temperature, stringency and time dependence of molecular interactions for the development of a DNA biochip. We are adapting this system and improve its robustness developing applications, as a 900 spots microarray identifying 65 mutations of the cystic fibrosis, for medical uses and industrial commercialization.
The immune system is a striking example of an integrated information system, engaged in coordinated host-protective activities. Organs-on-chip approach (OOC) models allow the direct simultaneous observation of hundreds of different cells, moving, interacting and responding to signals coming from the microenvironment nearby, that give access to a number of parameters describing the system that must be properly measured and elaborated.READ MORE