Building and Deploying Digital Pathology Infrastructure for a Heterogeneous User Base
Poster Oct 23, 2016
Silke Smeets, Stijn Piessens, Sabrina D'Haese, Chris Groven, Wim Waelput, Ramses Forsyth, Peter In't Veld
The flexibility of digital pathology hardware and software solutions today allows institutions to create bespoke solutions to meet individual user needs. We built a centralized infrastructure that integrates a variety of imaging platforms (brightfield, fluorescence, multivendor formats). Results: On top of this diversified hardware, a hybrid solution was compiled that consists of commercial software as well as open source packages. In order to mine these data efficiently, a topdown approach was employed to manage and integrate the various platforms. Custom coding was used to interact with various vendor software and server applications, where needed. Digital pathology involves much more than the acquisition of a slide scanner. At the VUB, we have engaged five different imaging platforms onto a single architecture. We are now storing data from all modalities in a single storage facility, and can manage it through a single access point. The endresult is an interconnected network of heterogeneous scalable information silos. We currently have three main use cases for WSI: education, biobanking, and telepathology. We have about 7 terabytes of data online, and serve 50 users across different research groups and departments.
This research project attempts to highlight the importance of sampling from multiple sites of the lungs of patients with Idiopathic Pulmonary Fibrosis. Examining the histopathology of the human lung samples with IPF shows varying levels of fibrosis in different sites of the lung. To ensure an accurate representation of a patient's lungs, it is important to obtain samples from multiple sites on the lobes of the lungs.READ MORE