Can a Unified Laboratory Intelligence Approach be Applied to E&L Studies?
Poster Dec 21, 2016
Graham A. McGibbon, Karim Kassam
Controlled extraction studies aim to obtain extensive analytical data for drug containers and medical devices, and therefore recognize compounds and materials that may generate safety and performance concerns. It is, however, a challenge to sift and interpret data to find extractable signals from different instruments, especially when using a variety of hyphenated chromatography–mass spectrometry analyses. Therefore informatics technologies and software automation of workflows are becoming key strategic considerations for identification, elucidation, and characterization of extractables and leachables (E&L).
Proteomics and Substrate Based MS Imaging of Xenobiotic Metabolising Enzymes in Ex Vivo Human Skin and a Human Living Skin Equivalent ModelPoster
Untargeted proteomics analysis showed that human skin and a commercially available living skin equivalent model exhibit a similar distribution of xenobiotic metabolising enzymes. A new technique, substrate based mass spectrometry imaging (SB-MSI) was developed during this study.READ MORE
Development and Assessment of Non-Infected and Infected Skin Models Using MALDI-MSIPoster
Infections have detrimental effects on wound healing leading to chronic wound formation. The use of labskin,a living skin model, in combination with mass spectrometry imaging, provides a good model for assessing wound healing factors.READ MORE
Exploiting Polypharmacology in Precision Oncology: Identification of Differential Kinase Off-targets Among Clinical PARP InhibitorsPoster
Can we use computational methods to identify previously unknown off-targets of PARP inhibitors that can explain their observed differences?READ MORE