Characterization of Protein and Protein Aggregates using Temperature-controlled Hollow-Fiber Flow-FFF
Poster May 05, 2015
Trevor Havard, Florian Meier, Evelin Moldenhauer, Soheyl Tadjiki, Thorsten Klein
Hollow-Fiber Flow Field-Flow Fractionation (HF5) [1,2] is a subtechnique of conventional Asymmetrical Flow Field-flow fractionation (AF4). While AF4 uses a rectangular separation chan-nel, the separation in HF5 takes place in a tubular channel consisting of semi-permeable hollow fibers, which are packed in a respective cartridge. The HF5-cartridge can be used as a disposable in a conventional Postnova AF2000 AF4-system offering fast analysis times, sterile conditions as well as a very good reproducibility. Hence, HF5 represents an excellent fractionation system for e.g., pharmaceutical and biotechnological applications.
Development and Assessment of Non-Infected and Infected Skin Models Using MALDI-MSIPoster
Infections have detrimental effects on wound healing leading to chronic wound formation. The use of labskin,a living skin model, in combination with mass spectrometry imaging, provides a good model for assessing wound healing factors.READ MORE
Exploiting Polypharmacology in Precision Oncology: Identification of Differential Kinase Off-targets Among Clinical PARP InhibitorsPoster
Can we use computational methods to identify previously unknown off-targets of PARP inhibitors that can explain their observed differences?READ MORE
Overcoming the Challenges of Analysing Ionic Polar Pesticides in FoodPoster
Here, the novel application of the Waters’ Torus DEA column is presented, showing the improved performance of a UPLC-MS/MS method for the underivatised
analysis of glyphosate and a selection of other anionic pesticides.