Chip’N’Fish : Novel Chemical Proteomics Platform for Rapid Identification of Small Molecule Drug Candidates Against Disease-Specific Targets

Introduction

Identification and selection of disease-specific targets is one of the most critical steps in post-genomic drug-discovery. Over-expression of genes and their protein products is often the best starting point for dissecting the pathways that are responsible for the development of specific diseases. Such proteins often serve as molecular targets particularly in cancer, where small molecules are designed to inhibit directly oncogenic proteins that are mutated or overexpressed.