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Chronic administration of a new therapeutic agent improves memory in a mouse model of Alzheimer’s disease with tau deposition.

Poster   Dec 13, 2017

 
Chronic administration of a new therapeutic agent improves memory in a mouse model of Alzheimer’s disease with tau deposition.
 
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Aurélie Joly-Amado, Malika Berrada, Ashley Zitnyar, Stephanie Radu Dave Morgan, Marcia Gordon.

 
 

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License

 
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OTHER POSTERS

Characterization of a Type 2 diabetes-associated islet-specific enhancer cluster in STARD10 by genome editing of EndoC-βH1 cells

Poster

Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes. The majority of these are located in the intergenic or intragenic regions suggesting that the implicated variants may alter chromatin conformation. This, in turn, is likely to influence the expression of nearby or more remotely located genes to alter beta cell function. At present, however, detailed molecular and functional analyses are still lacking for most of these variants. We recently analysed one of these loci and mapped five causal variants in an islet-specific enhancer cluster within the STARD10 gene locus. Here, we aimed to understand how these causal variants influence b-cell function by alteration of the chromatin structure of enhancer cluster

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Depression, Anxiety and Apathy in Young-Onset and Atypical Dementia: A systematic review

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This study aims to examine the body of empirical studies investigating the prevalence of depression, anxiety, and apathy in atypical and young-onset dementia.

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Psychiatric Risk Gene Cacna1c and Early Life Stress: Potential Gene-Environment interactions?

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Early life stress (ELS) is highly associated with development of psychopathology
and mood disorders in adulthood. Genetic studies have identified variation in the gene calcium voltage-gated channel subunit alpha1C (CACNA1C) to increase risk for several psychiatric disorders. This poster assessed the expression of Cacna1c following prepubertal stress.

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